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A Novel Mechanism of Lysosomal Acid Sphingomyelinase Maturation

Sphingomyelinase (SMase) can degrade sphingomyelin and generate phosphocholine and ceramide. There are several forms of SMase that differ by pH optima and subcellular localizations. Acid SMase can be secreted and it functions equally well at neutral pH [99-100].

Sphingomyelin phosphodiesterase - Wikipedia

Furthermore, we will discuss the family of neutral sphingomyelinases (N-SMases), which generate ceramide through the hydrolysis of sphingomyelin and are key enzymes in sphingolipid metabolism. Four mammalian N-SMase enzymes have now been identified.

SMAN 1 Sewon

A SMase assay kit is commercially available, based on the use of 10-acetyl-3,7-dihydroxyphenoxazine (Amplex Red), a sensitive fluorogenic probe for H 2 O 2. First, SMase hydrolyzes the sphingomyelin to yield ceramide and phosphorylcholine.

Sphingomyelinases: their regulation and roles in cardiovascular ...

The extended family of N-SMases is a subset of the DNaseI superfamily and comprises members from bacteria, yeast and mammals. In recent years, the identification and cloning of mammalian N-SMase family members has led to significant advances in understanding their physiological roles and regulation.

Acid sphingomyelinase inhibition suppresses lipopolysaccharide-mediated ...

nSMase2 has been extensively studied among the neutral forms of SMase because of its actual and major physiological activity 28. To examine the role of nSMase2 in starvation-induced autophagy...

Acid Sphingomyelinase - an overview | ScienceDirect Topics

SMASE-Africa is a network of 27 African countries that aims to strengthen mathematics and science education in the continent. It organizes conferences, webinars, publications and exchange visits to share innovative practices and research outcomes in STEM education.